Dr. Rachel van Swelm

Rachel van Swelm

Renal iron handling in health and disease. Specifically, current projects include investigating the role of distal tubular iron loading in progression of proteinuric kidney disease, studying the potential protective effect of hepcidin in iron-mediated acute kidney injury and elucidating uptake and potential harmful effects of hemoglobin in distal tubular epithelial cells.

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E-mail: Rachel.vanSwelm@radboudumc.nl

Follow Rachel van Swelm at http://www.linkedin.com/in/rachel-van-swelm-710a4613

Publications by Rachel van Swelm

Inhibition of Nrf2 alters cell stress induced by chronic iron exposure in human proximal tubular epithelial cells van Raaij SEG, Masereeuw R, Swinkels DW, van Swelm RPL. Toxicol Lett 2018;295:179.
Tubular iron deposition and iron handling proteins in human healthy kidney and chronic kidney disease van Raaij S, van Swelm R, Bouman K, Cliteur M, van den Heuvel M, Pertijs J, Patel D, Bass P, van Goor H, Unwin R, Srai SK, Swinkels D. Scientific Reports 2018;8(1):9353.
Sustained plasma hepcidin suppression and iron elevation by Anticalin-derived hepcidin antagonist in cynomolgus monkey Hohlbaum AM, Gille H, Trentmann S, Kolodziejczyk M, Rattenstetter B, Laarakkers CM, Katzmann G, Christian HJ, Andersen N, Allersdorfer A, Olwill SA, Meibohm B, Audoly LP, Swinkels DW, van Swelm RPL. Br J Pharmacol 2018;175(7):1054-1065.
Endogenous hepcidin synthesis protects the distal nephron against hemin and hemoglobin mediated necroptosis van Swelm RPL, Vos M, Verhoeven F, Thévenod F, Swinkels DW. Cell Death Dis 2018;9(5):550.
Dietary hemoglobin rescues young piglets from severe iron deficiency anemia: Duodenal expression profile of genes involved in heme iron absorption. Staroń R, Lipiński P, Lenartowicz M, Bednarz A, Gajowiak A, Smuda E, Krzeptowski W, Pieszka M, Korolonek T, Hamza I, Swinkels DW, Van Swelm RPL, Starzyński RR. PLoS ONE 2017; 12(7):e0181117.

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