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Anemia

Dietary hemoglobin rescues young piglets from severe iron deficiency anemia: Duodenal expression profile of genes involved in heme iron absorption.Staroń R, Lipiński P, Lenartowicz M, Bednarz A, Gajowiak A, Smuda E, Krzeptowski W, Pieszka M, Korolonek T, Hamza I, Swinkels DW, Van Swelm RPL, Starzyński RR. PLoS ONE 2016; 12(7):e0181117.

Renal physiology/disorders

Catalytic Iron and Acute Kidney InjuryLeaf DE, Swinkels DW. Am J Physiol Renal Physiol 2016. In press
Renal handling of circulating and renal-synthesized hepcidin and its protective effects against hemoglobin-mediated kidney injuryvan Swelm RP, Wetzels JF, Verweij VG, Laarakkers CM, Pertijs JC, van der Wijst J, Thévenod F, Masereeuw R, Swinkels DW. J Am Soc Nephrol 2016; 27(9):2720-32.
Hepcidin in chronic kidney disease: not an anaemia management tool, but promising as a cardiovascular biomarkervan der Weerd NC, Grooteman MP, Nubé MJ, ter Wee PM, Swinkels DW, Gaillard CA. Neth J Med 2015;73(3):108-18.
Hepcidin-25 is related to cardiovascular events in chronic haemodialysis patientsvan der Weerd NC, Grooteman MP, Bots ML, van den Dorpel MA, den Hoedt CH, Mazairac AH, Nubé MJ, Penne EL, Wetzels JF, Wiegerinck ET, Swinkels DW, Blankestijn PJ, Ter Wee PM; CONTRAST Investigators. Nephrol Dial Transplant. 2013;28(12):3062-71.
Tubular reabsorption and local production of urine hepcidin-25Peters HP, Laarakkers CM, Pickkers P, Masereeuw R, Boerman OC, Eek A, Cornelissen EA, Swinkels DW, Wetzels JF. BMC Nephrol. 2013;14:70.
Iron metabolism in the pathogenesis of iron-induced kidney injuryMartines AM, Masereeuw R, Tjalsma H, Hoenderop JG, Wetzels JF, Swinkels DW. Nat Rev Nephrol 2013;9(7):385-98.
Hepcidin-25 in chronic hemodialysis patients is related to residual kidney function and not to treatment with erythropoiesis stimulating agentsvan der Weerd NC, Grooteman MP, Bots ML, van den Dorpel MA, den Hoedt CH, Mazairac AH, Nubé MJ, Penne EL, Gaillard CA, Wetzels JF, Wiegerinck ET, Swinkels DW, Blankestijn PJ, Ter Wee PM; CONTRAST Investigators. PLoS One 2012;7(7):e39783.
Determinants of red cell distribution width (RDW) in cardiorenal patients: RDW is not related to erythropoietin resistanceEmans ME, van der Putten K, van Rooijen KL, Kraaijenhagen RJ, Swinkels D, van Solinge WW, Cramer MJ, Doevendans PA, Braam B, Gaillard CA. J Card Fail 2011;17(8):626-33.
Serum hepcidin-25 levels in patients with chronic kidney disease are independent of glomerular filtration ratePeters HP, Laarakkers CM, Swinkels DW, Wetzels JF. Nephrol Dial Transplant 2010;25(3):848-53.
Hepcidin-25 is a marker of the response rather than resistance to exogenous erythropoietin in chronic kidney disease/chronic heart failure patientsvan der Putten K, Jie KE, van den Broek D, Kraaijenhagen RJ, Laarakkers C, Swinkels DW, Braam B, Gaillard CA. Eur J Heart Fail. 2010;12(9):943-50.
Hepcidin serum levels and resistance to recombinant human erythropoietin therapy in haemodialysis patientsCosta E, Swinkels DW, Laarakkers CM, Rocha-Pereira P, Rocha S, Reis F, Teixeira F, Miranda V, do Sameiro Faria M, Loureiro A, Quintanilha A, Belo L, Santos-Silva A. Acta Haematol 2009;122(4):226-9.
Hepcidin: a new tool in the management of anaemia in patients with chronic kidney disease?Swinkels DW, Wetzels JF. Nephrol Dial Transplant 2008;23(8):2450-3.
Serum ferritin levels are increased in patients with glomerular diseases and proteinuriaBranten AJ, Swinkels DW, Klasen IS, Wetzels JF. Nephrol Dial Transplant 2004;19(11):2754-60.

Gut/Microbiome

Microbial metabolism shifts towards an adverse profile with supplementary iron in the TIM-2 In vitro model of the human colonKortman GA, Dutilh BE, Maathuis AJ, Engelke UF, Boekhorst J, Keegan KP, Nielsen FG, Betley J, Weir JC, Kingsbury Z, Kluijtmans LA, Swinkels DW, Venema K, Tjalsma H. Front Microbiol 2016;6:1481.
Iron fortification adversely affects the gut microbiome, increases pathogen abundance and induces intestinal inflammation in Kenyan infantsJaeggi T, Kortman GA, Moretti D, Chassard C, Holding P, Dostal A, Boekhorst J, Timmerman HM, Swinkels DW, Tjalsma H, Njenga J, Mwangi A, Kvalsvig J, Lacroix C, Zimmermann MB. Gut 2015;64(5):731-42.
Low dietary iron intake restrains the intestinal inflammatory response and pathology of enteric infection by food-borne bacterial pathogensKortman GA, Mulder ML, Richters TJ, Shanmugam NK, Trebicka E, Boekhorst J, Timmerman HM, Roelofs R, Wiegerinck ET, Laarakkers CM, Swinkels DW, Bolhuis A, Cherayil BJ, Tjalsma H. Eur J Immunol 2015;45(9):2553-67.
Iron-induced virulence of Salmonella enterica serovar typhimurium at the intestinal epithelial interface can be suppressed by carvacrolKortman GA, Roelofs RW, Swinkels DW, de Jonge MI, Burt SA, Tjalsma H. Antimicrob Agents Chemother 2014;58(3):1664-70.
Nutritional iron turned inside out: intestinal stress from a gut microbial perspectiveKortman GA, Raffatellu M, Swinkels DW, Tjalsma H. FEMS Microbiol Rev 2014;38(6):1202-34.

Infection/Inflammation

Hyperferritinemia and iron metabolism in Gaucher disease: Potential pathophysiological implicationsRegenboog M, van Kuilenburg AB, Verheij J, Swinkels DW, Hollak CE. Blood Rev 2016. In press
The aetiology of anaemia during pregnancy: a study to evaluate the contribution of iron deficiency and common infections in pregnant Ugandan womenBaingana RK, Enyaru JK, Tjalsma H, Swinkels DW, Davidsson L. Public Health Nutr 2015;18(8):1423-35.
The effect of iron loading and iron chelation on the innate immune response and subclinical organ injury during human endotoxemia: a randomized trialvan Eijk LT, Heemskerk S, van der Pluijm RW, van Wijk SM, Peters WH, van der Hoeven JG, Kox M, Swinkels DW, Pickkers P. Haematologica 2014;99(3):579-87.
Conventional and novel peripheral blood iron markers compared against bone marrow in Malawian childrenJonker FA, Boele van Hensbroek M, Leenstra T, Vet RJ, Brabin BJ, Maseko N, Gushu MB, Emana M, Kraaijenhagen R, Tjalsma H, Swinkels DW, Calis JC. J Clin Pathol 2014;67(8):717-23.
Effect of the antihepcidin Spiegelmer lexaptepid on inflammation-induced decrease in serum iron in humansvan Eijk LT, John AS, Schwoebel F, Summo L, Vauléon S, Zöllner S, Laarakkers CM, Kox M, van der Hoeven JG, Swinkels DW, Riecke K, Pickkers P. Blood 2014;124(17):2643-6.
The iron link between malaria and invasive non-typhoid Salmonella infectionsvan Santen S, de Mast Q, Swinkels DW, van der Ven AJ. Trends Parasitol 2013;29(5):220-7.
Inverse relationship of serum hepcidin levels with CD4 cell counts in HIV-infected patients selected from an Indonesian prospective cohort studyWisaksana R, de Mast Q, Alisjahbana B, Jusuf H, Sudjana P, Indrati AR, Sumantri R, Swinkels D, van Crevel R, van der Ven A. PLoS One 2013;8(11):e79904.
Low hepcidin levels in severely anemic malawian children with high incidence of infectious diseases and bone marrow iron deficiencyJonker FA, Calis JC, Phiri K, Kraaijenhagen RJ, Brabin BJ, Faragher B, Wiegerinck ET, Tjalsma H, Swinkels DW, van Hensbroek MB. PLoS One 2013;8(12):e78964.
Iron homeostasis in mother and child during placental malaria infectionVan Santen S, de Mast Q, Luty AJ, Wiegerinck ET, Van der Ven AJ, Swinkels DW. Am J Trop Med Hyg 2011;84(1):148-51.
Inflammation-induced hepcidin-25 is associated with the development of anemia in septic patients: an observational studyvan Eijk LT, Kroot JJ, Tromp M, van der Hoeven JG, Swinkels DW, Pickkers P. Crit Care 2011;15(1):R9.
Hepcidin in malaria superinfection: can findings be translated to humans?van Santen S, de Mast Q, Swinkels DW, van der Ven AJ. Nat Med 2011;17(11):1341.
Assessment of urinary concentrations of hepcidin provides novel insight into disturbances in iron homeostasis during malarial infectionde Mast Q, Nadjm B, Reyburn H, Kemna EH, Amos B, Laarakkers CM, Silalye S, Verhoef H, Sauerwein RW, Swinkels DW, van der Ven AJ. J Infect Dis 2009;199(2):253-62.
Mild increases in serum hepcidin and interleukin-6 concentrations impair iron incorporation in haemoglobin during an experimental human malaria infectionde Mast Q, van Dongen-Lases EC, Swinkels DW, Nieman AE, Roestenberg M, Druilhe P, Arens TA, Luty AJ, Hermsen CC, Sauerwein RW, van der Ven AJ. Br J Haematol 2009;145(5):657-64.
An insight into the relationships between hepcidin, anemia, infections and inflammatory cytokines in pediatric refugees: a cross-sectional studyCherian S, Forbes DA, Cook AG, Sanfilippo FM, Kemna EH, Swinkels DW, Burgner DP. PLoS One 2008;3(12):e4030.
Nitric oxide does not contribute to inflammation-induced hypoferremia in humansKemna EH, Pickkers P, Tjalsma H, Swinkels DW. Acta Haematol 2007;118(3):149-52.
Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPSKemna E, Pickkers P, Nemeth E, van der Hoeven H, Swinkels D. Blood 2005;106(5):1864-6.

Hereditary hemochromatosis

Second international round robin for the quantification of serum non-transferrin-bound iron and labile plasma iron in patients with iron-overload disordersde Swart L, Hendriks JC, van der Vorm LN, Cabantchik ZI, Evans PJ, Hod EA, Brittenham GM, Furman Y, Wojczyk B, Janssen MC, Porter JB, Mattijssen VE, Biemond BJ, MacKenzie MA, Origa R, Galanello R, Hider RC, Swinkels DW. Haematologica 2016;101(1):38-45.
Course of iron parameters in HFE-hemochromatosis patients during initial treatment with erythrocytapheresis compared to phlebotomyRombout-Sestrienkova E, Koek GH, Neslo R, van Kraaij M, Menheere PP, Masclee A, Swinkels DW. J Clin Apher 2016 [Epub ahead of print].
Correlates of hepcidin and NTBI according to HFE status in patients referred to a liver centreRyan E, Ryan JD, Russell J, Coughlan B, Tjalsma H, Swinkels DW, Stewart S, Crowe JP. Acta Haematol 2015;133(2):155-61.
The importance of the general practitioner as an information source for patients with hereditary haemochromatosisTeixeira E, Borlido-Santos J, Brissot P, Butzeck B, Courtois F, Evans RW, Fernau J, Nunes JA, Mullett M, Paneque M, Pineau B, Porto G, Sorrill R, Sanchez M, Swinkels DW, Toska K, Varkonyi J; EFAPH, the European Federation of Associations of Patients with
Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosisBenyamin B, Esko T, Ried JS, Radhakrishnan A, Vermeulen SH, Traglia M, Gögele M, Anderson D, Broer L, Podmore C, Luan J, Kutalik Z, Sanna S, van der Meer P, Tanaka T, Wang F, Westra HJ, Franke L, Mihailov E, Milani L, Hälldin J, Winkelmann J, Meitinger T,
Relevance of dietary iron intake and bioavailability in the management of HFE hemochromatosis: a systematic reviewMoretti D, van Doorn GM, Swinkels DW, Melse-Boonstra A. Am J Clin Nutr 2013;98(2):468-79.
Hemochromatosis (HFE) genotype and atherosclerosis: Increased susceptibility to iron-induced vascular damage in C282Y carriers?Engberink MF, Povel CM, Durga J, Swinkels DW, de Kort WL, Schouten EG, Verhoef P, Geleijnse JM. Atherosclerosis 2010;211(2):520-5.
Severity of iron overload of proband determines serum ferritin levels in families with HFE-related hemochromatosis: the HEmochromatosis FAmily StudyJacobs EM, Hendriks JC, van Deursen CT, Kreeftenberg HG, de Vries RA, Marx JJ, Stalenhoef AF, Verbeek AL, Swinkels DW. J Hepatol 2009;50(1):174-83.
Serum hepcidin levels are innately low in HFE-related haemochromatosis but differ between C282Y-homozygotes with elevated and normal ferritin levelsvan Dijk BA, Laarakkers CM, Klaver SM, Jacobs EM, van Tits LJ, Janssen MC, Swinkels DW. Br J Haematol 2008;142(6):979-85.
Changing aspects of HFE-related hereditary haemochromatosis and endeavours to early diagnosisJacobs EM, Verbeek AL, Kreeftenberg HG, van Deursen CT, Marx JJ, Stalenhoef AF, Swinkels DW, de Vries RA. Neth J Med 2007;65(11):419-24.
Morbidity and mortality in first-degree relatives of C282Y homozygous probands with clinically detected haemochromatosis compared with the general population: the HEmochromatosis FAmily Study (HEFAS)Jacobs EM, Hendriks JC, Marx JJ, van Deursen CT, Kreeftenberg HG, de Vries RA, Stalenhoef AF, Verbeek AL, Swinkels DW. Neth J Med 2007;65(11):425-33.

Transfusion medicine

The donation interval of 56 days requires extension to 180 days for whole blood donors to recover from changes in iron metabolismSchotten N, Pasker-de Jong PC, Moretti D, Zimmermann M, Geurts-Moespot A, Swinkels DW, van Kraaij MG. Blood 2016. In press
Donation intensity and metabolic syndrome in active whole-blood donorsPeffer K, Verbeek AL, Swinkels DW, Geurts-Moespot AJ, den Heijer M, Atsma F. Vox Sang. 2015;109(1):25-34.
The effect of frequent whole blood donation on ferritin, hepcidin, and subclinical atherosclerosisPeffer K, den Heijer M, Holewijn S, de Graaf J, Swinkels DW, Verbeek AL, Atsma F. Transfusion 2013;53(7):1468-74.

Clinical trials

Safety, pharmacokinetics and pharmacodynamics of the anti-hepcidin Spiegelmer lexaptepid pegol in healthy subjectsBoyce M, Warrington S, Cortezi B, Zöllner S, Vauléon S, Swinkels DW, Summo L, Schwoebel F, Riecke KBr J Pharmacol 2016. 173(10):1580-8
The donation interval of 56 days requires extension to 180 days for whole blood donors to recover from changes in iron metabolismSchotten N, Pasker-de Jong PC, Moretti D, Zimmermann M, Geurts-Moespot A, Swinkels DW, van Kraaij MG. Blood 2016. In press
Oral iron supplements increase hepcidin and decrease iron absorption from daily or twice-daily doses in iron-depleted young womenMoretti D, Goede JS, Zeder C, Jiskra M, Chatzinakou V, Tjalsma H, Melse-Boonstra A, Brittenham G, Swinkels DW, Zimmermann MB. Blood 2015;126(17):1981-9.
The effect of iron loading and iron chelation on the innate immune response and subclinical organ injury during human endotoxemia: a randomized trialvan Eijk LT, Heemskerk S, van der Pluijm RW, van Wijk SM, Peters WH, van der Hoeven JG, Kox M, Swinkels DW, Pickkers P. Haematologica 2014;99(3):579-87.
The effect of iron loading and iron chelation on the innate immune response and subclinical organ injury during human endotoxemia: a randomized trialvan Eijk LT, Heemskerk S, van der Pluijm RW, van Wijk SM, Peters WH, van der Hoeven JG, Kox M, Swinkels DW, Pickkers P. Haematologica 2014;99(3):579-87.
Effect of the antihepcidin Spiegelmer lexaptepid on inflammation-induced decrease in serum iron in humansvan Eijk LT, John AS, Schwoebel F, Summo L, Vauléon S, Zöllner S, Laarakkers CM, Kox M, van der Hoeven JG, Swinkels DW, Riecke K, Pickkers P. Blood 2014;124(17):2643-6.

Genetic epidemiology

Iron and hepcidin as risk factors in atherosclerosis: what do the genes say?Galesloot TE, Janss LL, Burgess S, Kiemeney LA, den Heijer M, de Graaf J, Holewijn S, Benyamin B, Whitfield JB, Swinkels DW, Vermeulen SH. BMC Genet 2015;16:79.
Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosisBenyamin B, Esko T, Ried JS, Radhakrishnan A, Vermeulen SH, Traglia M, Gögele M, Anderson D, Broer L, Podmore C, Luan J, Kutalik Z, Sanna S, van der Meer P, Tanaka T, Wang F, Westra HJ, Franke L, Mihailov E, Milani L, Hälldin J, Winkelmann J, Meitinger T,
Associations of common variants in HFE and TMPRSS6 with iron parameters are independent of serum hepcidin in a general population: a replication studyGalesloot TE, Geurts-Moespot AJ, den Heijer M, Sweep FC, Fleming RE, Kiemeney LA, Vermeulen SH, Swinkels DW. J Med Genet 2013;50(9):593-8.

Atherosclerosis

Iron and hepcidin as risk factors in atherosclerosis: what do the genes say?Galesloot TE, Janss LL, Burgess S, Kiemeney LA, den Heijer M, de Graaf J, Holewijn S, Benyamin B, Whitfield JB, Swinkels DW, Vermeulen SH. BMC Genet 2015;16:79.
Serum hepcidin is associated with presence of plaque in postmenopausal women of a general populationGalesloot TE, Holewijn S, Kiemeney LA, de Graaf J, Vermeulen SH, Swinkels DW. Arterioscler Thromb Vasc Biol 2014;34(2):446-56.
The effect of frequent whole blood donation on ferritin, hepcidin, and subclinical atherosclerosisPeffer K, den Heijer M, Holewijn S, de Graaf J, Swinkels DW, Verbeek AL, Atsma F. Transfusion 2013;53(7):1468-74.
Serum hepcidin and macrophage iron correlate with MCP-1 release and vascular damage in patients with metabolic syndrome alterationsValenti L, Dongiovanni P, Motta BM, Swinkels DW, Bonara P, Rametta R, Burdick L, Frugoni C, Fracanzani AL, Fargion S. Arterioscler Thromb Vasc Biol. 2011;31(3):683-90.
Serum ferritin levels are associated with vascular damage in patients with nonalcoholic fatty liver diseaseValenti L, Swinkels DW, Burdick L, Dongiovanni P, Tjalsma H, Motta BM, Bertelli C, Fatta E, Bignamini D, Rametta R, Fargion S, Fracanzani AL. Nutr Metab Cardiovasc Dis. 2011;21(8):568-75.
Hemochromatosis (HFE) genotype and atherosclerosis: Increased susceptibility to iron-induced vascular damage in C282Y carriers?Engberink MF, Povel CM, Durga J, Swinkels DW, de Kort WL, Schouten EG, Verhoef P, Geleijnse JM. Atherosclerosis 2010;211(2):520-5.

Sports

Seven days of high carbohydrate ingestion does not attenuate post-exercise IL-6 and hepcidin levelsBadenhorst CE, Dawson B, Cox GR, Sim M, Laarakkers CM, Swinkels DW, Peeling P. Eur J Appl Physiol 2016. 116(9):1715-24
Live high, train low - influence on resting and post-exercise hepcidin levelsGovus AD, Peeling P, Abbiss CR, Lawler NG, Swinkels DW, Laarakkers CM, Thompson KG, Peiffer JJ, Gore CJ, Garvican-Lewis LA. Scand J Med Sci Sports 2016. In press
Timing of post-exercise carbohydrate ingestion: influence on IL-6 and hepcidin responsesBadenhorst CE, Dawson B, Cox GR, Laarakkers CM Swinkels DW, Peeling P. Eur J Appl Physiol. 2015;115(10):2215-22
Oral contraception does not alter typical post-exercise interleukin-6 and hepcidin levels in femalesSim M, Dawson B, Landers G, Swinkels DW, Tjalsma H, Yeap BB, Trinder D, Peeling P. J Sci Med Sport. 2015;18(1):8-12.
Acute dietary carbohydrate manipulation and the subsequent inflammatory and hepcidin responses to exerciseBadenhorst CE, Dawson B, Cox GR, Laarakkers CM, Swinkels DW, Peeling P. Eur J Appl Physiol. 2015;115(12):2521-30
Iron status and the acute post-exercise hepcidin response in athletesPeeling P, Sim M, Badenhorst CE, Dawson B, Govus AD, Abbiss CR, Swinkels DW, Trinder D. PLoS One. 2014;9(3):e93002.
A seven day running training period increases basal urinary hepcidin levels as compared to cyclingSim M, Dawson B, Landers GJ, Swinkels DW, Tjalsma H, Wiegerinck ET, Trinder D, Peeling P. J Int Soc Sports Nutr. 2014;11(1):14.
Acute hypoxic exercise does not alter post-exercise iron metabolism in moderately trained endurance athletesGovus AD, Abbiss CR, Garvican-Lewis LA, Swinkels DW, Laarakkers CM, Gore CJ, Peeling P. Eur J Appl Physiol. 2014;114(10):2183-91
Effect of exercise modality and intensity on post-exercise interleukin-6 and hepcidin levelsSim M, Dawson B, Landers G, Swinkels DW, Tjalsma H, Trinder D, Peeling P. Int J Sport Nutr Exerc Metab. 2013;23(2):178-86.
The effects of carbohydrate ingestion during endurance running on post-exercise inflammation and hepcidin levelsSim M, Dawson B, Landers G, Wiegerinck ET, Swinkels DW, Townsend MA, Trinder D, Peeling P. Eur J Appl Physiol. 2012;112(5):1889-98.
Training surface and intensity: inflammation, hemolysis, and hepcidin expressionPeeling P, Dawson B, Goodman C, Landers G, Wiegerinck ET, Swinkels DW, Trinder D. Med Sci Sports Exerc. 2009;41(5):1138-45.
Cumulative effects of consecutive running sessions on hemolysis, inflammation and hepcidin activityPeeling P, Dawson B, Goodman C, Landers G, Wiegerinck ET, Swinkels DW, Trinder D. Eur J Appl Physiol. 2009;106(1):51-9
Effects of exercise on hepcidin response and iron metabolism during recoveryPeeling P, Dawson B, Goodman C, Landers G, Wiegerinck ET, Swinkels DW, Trinder D. Int J Sport Nutr Exerc Metab. 2009;19(6):583-97

Neurology

Disrupted iron regulation in the brain and periphery in cocaine addictionErsche KD, Acosta-Cabronero J, Jones PS, Ziauddeen H, van Swelm RP, Laarakkers CM, Raha-Chowdhury R, Williams GB. Transl Psychiatry 2017;7(2):e1040.

Cardiovascular

Cardiac Hepcidin Expression Associates with Injury Independent of Iron.van Breda GF, Bongartz LG, Zhuang W, van Swelm RP, Pertijs J, Braam B, Cramer MJ, Swinkels DW, Doevendans PA, Verhaar MC, Masereeuw R, Joles JA, Gaillard CA. Am J Nephrol 2016;44(5):368-378.